Precautions should be used in patients with severe impaired renal function.
Precautions should be used in patients with severe disturbances of liver function.Īn overdose of the drug can cause liver failure.Īpplication for violations of renal function
The drug is contraindicated during pregnancy and lactation.Īpplication for violations of liver function Use of the drug Trigano-D during pregnancy and breastfeeding Precautions should be used in patients with severe disorders of the liver or kidneys, if the genetic absence of glucose-6-phosphate dehydrogenase, blood diseases, glaucoma, benign hyperbilirubinemia (including Gilbert's syndrome), viral hepatitis, alcoholic liver damage, alcoholism, old age. Peptic ulcer and 12 duodenal ulcer (acute phase) Hypersensitivity to paracetamol and ditsikloverinu On the part of the genitourinary system: Piura, urinary retention, interstitial nephritis, papillary necrosis.įrom the side of view: mydriasis, blurred vision, cycloplegia, increased vnetriglaznogo Dahlen.Ĭontraindications to the use of the drug Trigano-D Quired for central nervous system (usually develops when taking high doses): drowsiness, dizziness, psychomotor agitation, and disorientation.įrom the Endocrine: hypoglycemia, up to hypoglycemic coma.įrom the side of blood: anemia, methemoglobinemia (cyanosis, shortness of breath, pain in the heart), hemolytic anemia (especially for patients with deficiency of gluco-6-phosphate dehydrogenase).
Trigan d uses skin#
On the part of the gastrointestinal tract: dry mouth, loss of taste, loss of appetite, epigastric pain, constipation, increased liver enzymes, usually without the development of jaundice, gepatonekroz (dose-dependent effect).Īllergic reactions: skin rash, itching, urticaria, Quincke's edema, erythema multiforme exudative (including Stevens-Johnson syndrome), toxic epidermal necrolysis (Lyell's syndrome). Prolonged use of the drug is necessary to monitor patterns of peripheral blood and functional state of the liver.ĭo not exceed the daily dose, increasing it or more prolonged treatment is possible only under medical supervision, because overdose of the drug can cause liver failure. The duration of intake without consulting a physician not more than 5 days when administered as an analgesic and 3 days - as a febrifuge. Used inside adults and children over 15 years: 1 tablet 2-3 The maximum single dose for adults is 2 tablets, 4 tablets daily. Infectious and inflammatory diseases accompanied by fever. Headache, toothache, migraine headache Spasm of smooth muscles of internal organs Indications for use of the drug Trigano-D About 80% of the drug excreted in the urine and in small numbers in the faeces. Paracetamol is metabolized in the liver with the formation of several metabolites, one of which is N-acetyl-benzohinomin under certain conditions (an overdose of medication, lack of glutathione in the liver) could have a damaging effect on the liver and kidneys. C max plasma levels achieved after 60-90 min. The drug is well absorbed in the gastrointestinal tract. The combined effect of two components Trigano-D provides a relaxation spasm of smooth muscles of internal organs and reducing pain. At therapeutic doses, is effective relaxation of smooth muscles, which is not accompanied by side effects typical of atropine. The second component ditsikloverina tertiary amine hydrochloride, which has a relatively weak non-selective M-anticholinergic and direct miotropnym antispasmodic effect on smooth muscles of internal organs. The mechanism of action is associated with a moderate inhibition of cyclooxygenase-1 and to a lesser extent COX-2 in peripheral tissues and central nervous system, resulting in the inhibition of prostaglandin biosynthesis modulators of pain sensitivity, thermoregulation and inflammation. Incoming in the drug paracetamol has analgesic, antipyretic and anti-inflammatory effects negligible.
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